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In this work, we use an unsupervised method for generating binary class labels in a novel context to create class labels for Medicare fraud detection. We examine how class imbalance influences the quality of these new labels and how it affects supervised classification. We use four different Medicare Part D fraud detection datasets, with the largest containing over 5 million instances. The other three datasets are sampled from the original dataset. Using Random Under-Sampling (RUS), we subsample from the majority class of the original data to produce three datasets with varying levels of class imbalance. To evaluate the performance of the newly created labels, we train a supervised classifier and evaluate its classification performance and compare it to an unsupervised anomaly detection method as a baseline. Our empirical findings indicate that the generated class labels are of high enough quality and enable effective supervised classifier training for fraud detection. Additionally, supervised classification with the new labels consistently outperforms the baseline used for comparison across all test scenarios. Further more, we observe an inverse relationship between class imbalance in the dataset and classifier performance, with AUPRC scores improving as the training dataset becomes more balanced. This work not only validates the efficacy of the synthesized class labels in labeling Medicare fraud but also shows its robustness across different degrees of class imbalance.